Dr. Vandana Andrews
General Practitioner
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Patient's Query
Hello doctor,
I am scheduled for a gastroscopy to rule out cancer. What do these biopsy results mean?
My biopsy results are as follows:
Antrum biopsy:
Presence of gastric antral type mucosa with mild to moderate reactive gastropathy and focal erosive changes.
No H. pylori-like organisms were identified by immunohistochemistry.
Negative for intestinal metaplasia or dysplasia.
Alcian blue stain is negative for goblet cells.
Middle esophagus biopsy:
Minimal chronic esophagitis with no eosinophilic esophagitis.
A normal fragment of gastric body-type mucosa is observed.
Special and IHC stains conducted with appropriate controls:
Ki67 shows low basal proliferation.
P53 is wild-type (normal).
Thank you.
Hello,
Welcome to icliniq.com.
We feel glad that you reached out to us.
Based on the outcomes of your biopsy, there is no indication of cancer or precancerous alterations in either the antrum of your stomach or the middle section of your esophagus (referred to as Barrett's esophagus biopsy).
The "antrum biopsy" reveals mild to moderate reactive gastropathy (inflammation or damage without ulcers) and focal erosive changes, which are nonspecific findings associated with various factors like infection, inflammation, or medication use. However, they do not suggest cancer or abnormal cell growth (dysplasia).
The "B middle esophagus biopsy" shows minimal chronic esophagitis (persistent inflammation of the esophagus) without eosinophilic esophagitis or Barrett's esophagus, a condition linked to an increased risk of esophageal cancer. Special and IHC (immunohistochemistry) stain results are normal. The Ki67 and p53 (tumor suppressor gene) tests, assessing cell proliferation and mutations, respectively, display normal results, further supporting the absence of cancer or dysplasia. While these results suggest no cancer or precancerous changes, I suggest adhering to any recommended follow-up care and monitoring as advised by your doctor.
I hope this helps.
Revert in case of other queries.
Thank you.
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General Practitioner
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